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翻譯編輯

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機轉編輯

例子編輯

aniline and der.:解熱鎮痛藥(Antipyretic analgesics,無抗發炎效果編輯

每包含有 500mg 的乙醯胺酚和 65mg 的咖啡因,成份跟「普拿疼加強錠」一樣,不過加了葡萄萃取物

glucocorticoids:類固醇消炎藥:解熱鎮痛消炎藥(antipyretic antiinflammatory analgesics編輯

glucocorticoids

NSAIDs(NSAIAs):非類固醇消炎藥:解熱鎮痛消炎藥(antipyretic antiinflammatory analgesics編輯

2016 aspirin NSAIAs besides aspirin
MOA inhibit COX I and II by irreversible mechanism of acetylation. inhibit COX I and COX II or COX II reversiblly
antiinnflammtion yeah yeah
cancer prevention yeah yeah
effect toward blood anticoagulate increase possibility of stroke (both COX II selective and nonselective)
ADR gastric, kidney gastric ( except for COX II selective:however, its coagulating effect act on heart ... .  ), kidney

pyrazolones:已不用於解熱鎮痛消炎,只用於抗痛風編輯

carboxylic acid編輯

salicylic acid and der.編輯
N-arylanthranilic acid(fenamic acid)編輯
acetic acid編輯
propionic acid(profen):more pottent and safer than acetate der., optic active 編輯

oxicam(enocarboxamide)(4-hydroxy-1,2-benzothiazine carboxamide)編輯

COX 2 selective inhibitors編輯

oxicam(enocarboxamide)(4-hydroxy-1,2-benzothiazine carboxamide)編輯

carboxylic acid-acetic acid der.編輯

etodolac

sulide編輯

coxib編輯

中藥編輯

  • 桂枝湯:有發汗時用
  • 葛根湯:項背強脊用

成藥基準表甲類成藥(一)解熱鎮痛劑:感冒、頭痛、解熱、鎮痛、風濕病、神經痛、齒痛、咽喉病、肩痛、鼻塞、流鼻水。編輯

  • 乙醯水楊酸(Acetylsalicylic Acid)
  • 咖啡鹼(Caffeine)
  • 氯芬尼拉明(Chlorpheniramine)
  • 汎司(Acetaminophen)
  • 水楊酸胺(Salicylamide)
  • 乙氧基胺(Ethoxybenzamide)
  • 溴滑利尿素(Bromvalerylurea)
  • 葛根(Pueraria)
  • 麻黃(Ephedra)
  • 升麻(Cimicifugae)
  • 柴胡(Bupleurum)
  • 桂皮(Cinnamomum)
  • 芍藥(Paeonia)
  • 大棗(Zizyphus)
  • 生薑(Zingiber)
  • 甘草(Glycyrrhiza)
  • 桔梗(Platycodon)
  • 白芷(Angelica Glaurao)

NSAIAs臨床上分法編輯

Nonselective NSAIAs編輯

Aspirin

Preferentially COX II編輯

Meloxicam, Nimesulide

Specific COX II編輯

延伸學習編輯

藥品學名 year introduced dose COX2 selectivity Biotransformation & excretion duration 其他
salicylate pharmacophore: aspirin 1899
Acetic acid derivatives pharmacophore: indomethacine 1965
anthranilic acid pharmacophore: mefenamic acid 1967
Propionic acid derivatives pharmacophore: ibuprofen 1974
Propionic acid derivatives pharmacophore: fenoprofen 1976
Propionic acid derivatives pharmacophore: naproxen 1976
Acetic acid derivatives pharmacophore: tolmetin 1976 no antigout activity
Acetic acid derivatives pharmacophore: sulindac 1978
anthranilic acid pharmacophore: meclofenamate 1980
salicylate pharmacophore: diflunisal 1982
oxicam pharmacophore: piroxicam 1982
Propionic acid derivatives pharmacophore: ketoprofen 1986
Propionic acid derivatives pharmacophore: flubiprofen 1988
acetic acid derivatives pharmacophore: diclofenac 1989
acetic acid derivatives pharmacophore: etodolac 1991
acetic acid derivatives pharmacophore: nabumetone 1992
propionic acid derivatives pharmacophore: oxaprozin 1993
coxib pharmacophore: Celecoxib(Celebrex) (withdrawal) 1999
coxib pharmacophore: Rofecoxib(withdrawal) 1999
oxicam pharmacophore: meloxicam 2000

外部連結編輯

  • [health.businessweekly.com.tw/AArticle.aspx?id=ARTL000006345 健康成人一天普拿疼劑量勿逾4公克 一顆止痛藥 會殘留體內5年?]

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