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定義編輯

  • 典型抗憂鬱藥的一種
  • The selective serotonin re-uptake inhibitors(SSRIs) are a group of chemically unique antidepressant drugs that specifically inhibit serotonin re-uptake( inhibit SERT), having 300-to 3000-fold greater selectivity as compared to the norepinephrine transporter.

和TCA的比較編輯

機轉編輯

  • SSRls block the re-uptake of serotonin, leading to increased concentrations of the neurotransmitter in the synaptic clefts.
  • Antidepressants, including SSRls, typically take two weeks to produce improvement in mood, and maximum benefit may require twelve weeks or more.
  • Patients that do not respond to one antidepressant may respond to another.

治療學編輯

例子編輯

副作用編輯

  • The SSRls can cause gastrointestinal effects, weakness, sexual dysfunction, sleep disturbances, and drug interactions.

對CNS的影響編輯

  • Paroxetine and fluvoxamine are sedating, and may be useful in patients who have difficulty sleeping.
  • Conversely, patients who are fatigued may benefit from one of the more activating antidepressants, fluoxetine.
  • Large intakes of SSRls do not cause cardiac arrhythmias, but fluoxetine may cause seizures.
  • Antidepressants should be used cautiously in children and teenagers, because about one out of fifty children become more suicidal as a result of SSRl treatment.

sexual dysfunction編輯

  • SSRl-induced sexual dysfunction can be replaced by the antidepressant with fewer sexual side effects, such as atypical one bupropion or mirtazapine.

serotonin syndrome編輯

  • All SSRls have the potential to cause a serotonin syndrome characterized by hyperthermia, muscle rigidity, myoclonus (clonic muscle twitching), and changes in mental status and vital signs when used in the presence of a monoamine oxidase inhibitor. Therefore, extended periods of wash-out of each drug class must occur prior to the administration of the other class of drugs.

相關條目編輯

參考資料編輯

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