Phenothiazines

• 此類骨架通常當作抗精神病藥(N10上有三個碳的鏈時)
  • 如果N10上是兩個碳的鏈時通常是抗組織胺或是抗膽鹼性藥物(像是帕金森氏症藥物)

個論

Phenothiazines

H1 antihistamine

• promethazine
• trimeprazine
• methdilazine

Propylamine side-chain

• Promazine
• prototype:Chlorpromazine: 止吐藥
• Triflupromazine

Piperidine side-chain

• Thioridazine
• Mesoridazine
• Piperacetazine

Piperazine side-chain

• Prochlorperazine: 止吐藥
• Trifluoperazine
• Thiethylperazine
• Perphenazine
• Fluphenazine
• Acetophenazine
• Carphenazine

Phenothiazines-likes

Thioxanthenes

• Chlorprothixene
• Thiothixene

Dibenzoxazepines

• Loxapine

Dibenzothiazepines

• Quetiapine
• Metiapine
• Clothiapine

Dibenzodiazepines

• clozapine

Thienobenzodiazepines

• Olanzapine

註:抗精神病分類

TIPICAL

弱效

• Chlorpromazine: Phenothiazines:Propylamine side-chain
• Thioridazine: Phenothiazines:Piperidine side-chain
• Prochlorperazine: Phenothiazines:Piperazine side-chain

強效

• Fluphenazine: Phenothiazines:Piperazine side-chain
• Thiothixene :Phenothiazines-likes:Thioxanthenes
• Haloperidol :Fluorobutyrophenones
• Pimozide:Fluorobutyrophenones

ATYPICAL

• clozapine:Phenothiazines-likes:Dibenzodiazepines
• Quetiapine:Phenothiazines-likes:Dibenzothiazepines
• Olanzapine:Phenothiazines-likes:Thienobenzodiazepines
• Risperidone:Fluorobutyrophenones

例子

• 抗精神病藥
• 抗組織胺
• 抗膽鹼性藥物