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鋰鹽Lithium salt) 主要機轉為抑制PI turnover而降低細胞的興奮性。

  1. 臨床上最需要監測的副作用是甲狀腺、腎臟、心臟毒性。
  2. Thiazide diuretics會升高lithium血中濃度。
  3. 血中治療濃度範圍為:0.5~1.5mEq/L。
  4. 預防Bipolar manic-depressive(兩極性躁鬱症)精神病。


翻譯編輯

鋰鹽

治療學編輯

  • 躁症
  • 躁鬱症的躁症狀態
  • 原文:Lithium salts are used prophylactically for treating manic-depressive patients and in the treatment of manic episodes. They are also effective in treating sixty to eighty percent of patients exhibiting mania and hypomania.

機轉編輯

  • The mode of action is unknown. [Note: lithium is believed to attenuate signaling via receptors coupled to the phos-phatidylinositol bisphosphate (PIP2) second messenger system. Lithium interferes with the resynthesis (recycling) of PIP2, leading to its relative depletion in neuronal membranes of the CNS. PIP2 levels in peripheral membranes are unaffected by lithium.]
  • Lithium causes no noticeable effect on normal individuals. It is not a sedative, euphoriant, or [The antiepileptic drugs carbamazepine and valproic acid have been shown to alleviate some of the symptoms of mania.]

毒性編輯

參考資料編輯

相關條目編輯

antimanics

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