main article:Taiwanese Antibacterial antibiotics classification抗菌抗生素分類
抗藥性[]
- chloramphenicol acetyltransferase
機轉[]
抑制蛋白質合成:藉由block step2 tranpeptidation抑制elongation by binding to 50s，屬於special purpose antibiotics
治療學[]
- meningitis: alternative to beta-lactam antibiotics for treatment of meningococcal meningitis or penicillin-resistant pneumococci
- rickettsial infections
毒性[]
- 為了避免血液毒性出現在新生兒身上，他的劑量必須控制在50mg/kg/d or less in full-term infants more than 1 week old (during the first week of life ) and 25 mg/kg/d in premature infants
藥物交互作用[]
- it inhibits hepatic microsomal enzymes and prolong serum conc. of Phenytoin, tolbutamide, chlopropamide, and Warfarin.
- like other bacteriostatic antibiotics inhibiting pt. synthesis, chloramphenicol also antagonize bactericidal antibiotics like penicillins and aminoglycoside