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來源
~mycin ~micin
Streptomyces Micromonospora

抗藥性編輯

例子編輯

機轉編輯

  • 抑制initiation(所以殺菌)
  • 和elongation by binding to 30s(irreversible)
  • 造成DNA的誤讀,但是spectinomycin(IM)不會

治療學編輯

配伍編輯

毒性編輯

  • 腎毒性和耳毒性
    • 腎毒性:reversible
    • 耳毒性:irreversible
  • if used in pregnancy, it may cause deafness in newborn.
  • toxicity is both concentration-dependent and time-dependent
  • if the trough conc.(波谷濃度) is above 2μg/ml , toxicity may happen.
  • toxicity is less possible to happen in Once daily dosing
    • if the therapy is longer than 2~3 days, serum conc. need be routinely checked, depends on renal function.
  • If streptomycin was used over 6 months in TB, the toxicity may happen
  • if used with loop diuretics may potentiate nephrotoxicity.
  • 高劑量的時候可能會像curare一樣產生作用:give calcium gluconate (give promptly) or neostigmine 解毒

重點編輯

延伸學習編輯

參考資料編輯

藥品學名 非糖 糖(胺糖) 其他
neomycin B 2-deoxystreptamine *neosamine C(2,6-diamino-2,6-dideoxy-D-glucose)(6-amino-6-deoxy-D-glucosamine)和2-deoxystreptamine合稱neamine 四個環、和paramomycin I差在D-glucosamine
neomycin C 2-deoxystreptamine *neosamine C和2-deoxystreptamine合稱neamine 四個環、和paramomycin II差在D-glucosamine
paramomycin I 2-deoxystreptamine *D-glucosamine2-deoxystreptamine合稱paromamine 四個環、和Neomycin B差在neosamine C
paramomycin II 2-deoxystreptamine *D-glucosamine(2-amino-2-deoxy-D-glucose)和2-deoxystreptamine合稱paromamine 四個環、和Neomycin C差在neosamine C
kanamycin 2-deoxystreptamine kanosamine(3-amino-3-deoxy-D-glucose) 三個環
kanamycin A 2-deoxystreptamine kanosamine、6-amino-6-deoxy-D-glucose 三個環
kanamycin B 2-deoxystreptamine kanosamine、2,6-diamino-2,6-dideoxy-D-glucose(6-amino-6-deoxy-D-glucosamine)(neosamine C) 三個環
kanamycin C 2-deoxystreptamine kanosamine、2-amino-2-deoxy-D-glucose(D-glucosamine) 三個環
amikacin L-AHBA2-deoxystreptamine kanosamine、6-amino-6-deoxy-D-glucose(kanamycin A der.) 三個環
tobramycin 2-deoxystreptamine kanosamine、kanamycin B der. 三個環
gentamicin 2-deoxystreptamine garosamine 三個環
netilmicin 2-deoxystreptamine garosamine、含雙鍵的胺糖 三個環
sisomicin 2-deoxystreptamine garosamine、含雙鍵的胺糖 三個環
streptomycin streptidine streptobiosamine= L-streptose + N-methyl-L-glucosamine 三個環
spectinomycin spectinamine 三個環

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